This documentation covers IPython versions 6.0 and higher. Beginning with version 6.0, IPython stopped supporting compatibility with Python versions lower than 3.3 including all versions of Python 2.7.
If you are looking for an IPython version compatible with Python 2.7, please use the IPython 5.x LTS release and refer to its documentation (LTS is the long term support release).
Any of the options listed here can be set in config files, at the command line, or from inside IPython. See Setting configurable options for details.